Trifluoperazine hydrochloride (VAN)
Trifluoperazine hydrochloride
CAS: 440-17-5
Molecular Formula: C21H26Cl2F3N3S
Trifluoperazine hydrochloride (VAN) - Names and Identifiers
Trifluoperazine hydrochloride (VAN) - Physico-chemical Properties
| Molecular Formula | C21H26Cl2F3N3S |
| Molar Mass | 480.42 |
| Melting Point | 243°C (dec.)(lit.) |
| Boling Point | 506°C at 760 mmHg |
| Flash Point | 9℃ |
| Solubility | ethanol: soluble5mg/mL |
| Vapor Presure | 2.32E-10mmHg at 25°C |
| Appearance | powder |
| Color | white to off-white |
| Maximum wavelength(λmax) | ['312nm(MeOH)(lit.)'] |
| Merck | 14,9680 |
| BRN | 3820024 |
| pKa | pK1 3.9, pK2 8.1(at 25℃) |
| Storage Condition | -20°C |
| Stability | Hygroscopic |
| Use | For the treatment of delusional schizophrenia, chronic schizophrenia, disturbed spirit, emotional disorders, Nausea, Vomit, etc |
| In vitro study | Trifluoperazine binds to α1A-and α1B-adrenoceptors with Ki values of 27.6 nM and 19.2 nM, respectively, and an α1B/α1A ratio of 0.7. Trifluoperazine inhibits Mycobacterium tuberculosis (Mtb) with a MICs of 7.6 μg/mL. Trifluoperazine (< 14.78 mM) dose-dependently inhibits mouse spleen NK cytotoxic activity and effector-target cell engagement. Trifluoperazine inhibits the increase in NK cytotoxic activity induced by interferon-alpha or interleukin-2. Trifluoperazine inhibits voltage-dependent potassium channel Kv2.1 from gene expression in the human brain (hKv2.1). |
| In vivo study | In rats with behavioral maintenance under intermittent test avoidance, Trifluoperazine dose-dependently reduced avoidance responses and increased response lapses. |
Trifluoperazine hydrochloride (VAN) - Risk and Safety
| Hazard Symbols | Xn - Harmful |
| Risk Codes | 22 - Harmful if swallowed |
| Safety Description | 36 - Wear suitable protective clothing. |
| UN IDs | UN1230 - class 3 - PG 2 - Methanol, solution |
| WGK Germany | 3 |
| RTECS | SP1750000 |
| FLUKA BRAND F CODES | 3-10 |
| HS Code | 29343000 |
Trifluoperazine hydrochloride (VAN) - Standard
Authoritative Data Verified Data
This product is 10-[3-(4-methyl-1-pivacanyl) propyl H (trifluoromethyl) phenothiazine dihydrochloride. The content of C21H24F3N3S • 2HC1 shall not be less than 99.0% calculated as dry products.
Last Update：2024-01-02 23:10:35
Trifluoperazine hydrochloride (VAN) - Trait
Authoritative Data Verified Data
- This product is a white to yellowish crystalline powder; Odorless or almost odorless; Slightly hygroscopic; Light gradual discoloration.
- This product is soluble in water, soluble in ethanol, slightly soluble in three gas methane, insoluble in ether.
Last Update：2022-01-01 14:20:08
Trifluoperazine hydrochloride (VAN) - Differential diagnosis
Authoritative Data Verified Data
- take about 20mg of this product, add 5ml of water to dissolve, and then add 1 ml of dilute nitric acid to generate a white precipitate with microstrip red color; After placing, the red color becomes darker, and changes to yellow after heating.
- take about 1ml of sulfuric acid solution of potassium dichromate (1-100), put it in a small test tube, turn the test tube, the solution should be evenly coated on the tube wall; Then add about several milligrams of fine powder of this product, slightly heat, turn the test tube, the solution should not be evenly coated on the pipe wall, and similar to the oil scale exists in the pipe wall.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 317).
- the aqueous solution of this product can identify the reaction of (1) (General rule 0301).
Last Update：2022-01-01 14:20:09
Trifluoperazine hydrochloride (VAN) - Exam
Authoritative Data Verified Data
acidity
take l.Og of this product, add water to dissolve 20ml, and then determine it according to law (General rule 0631). The pH value should be 1.7~2.6.
Related substances
take this product, add mobile phase to dissolve and dilute to make a solution containing 0.5mg per lml, as a test solution; Take appropriate amount of precision, A solution containing 2.5ug per 1 ml was prepared as a control solution by dilution with the mobile phase. According to the test of high performance liquid chromatography (General 0512), silica gel was bonded with eighteen alkyl silane as filler; 1.45% D-camphorsulfonic acid solution (adjusted to pH 3.0 with 1 mol/L sodium hydroxide solution)-Methanol (1:4) as mobile phase, detection wavelength of 259nm, the number of theoretical plate according to trifluoperazine peak is not less than 5000. 20 u1 of control solution and 20 u1 of test solution were respectively injected into human liquid chromatograph, and the chromatogram was recorded to 3 times of the retention time of principal component peak. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be greater than the area of the main peak of the control solution (0.5%), and the sum of each impurity peak area shall not be greater than 2 times the area of the main peak of the control solution (1.0%).
loss on drying
take this product, dry to constant weight at 105°C, weight loss shall not exceed 1.0% (General rule 0831).
ignition residue
not more than 0.1% (General rule 0841).
Last Update：2022-01-01 14:20:09
Trifluoperazine hydrochloride (VAN) - Content determination
Authoritative Data Verified Data
take this product about 0.2g, precision weighing, add anhydrous formic acid 10ml and acetic anhydride 40ml dissolved, according to the potential titration method (General rule 0701), with perchloric acid titration solution (0.1 mol/L) titration, and the results of the titration were corrected with a blank test. Each 1 ml of perchloric acid titration solution (0.1 mol/L) corresponds to 24.02mg of c21h24f3n3s.2hcl.
Last Update：2022-01-01 14:20:10
Trifluoperazine hydrochloride (VAN) - Category
Authoritative Data Verified Data
antipsychotics, antiemetics.
Last Update：2022-01-01 14:20:11
Trifluoperazine hydrochloride (VAN) - Storage
Authoritative Data Verified Data
light-shielded, sealed, and stored in a dry place.
Last Update：2022-01-01 14:20:11
Trifluoperazine hydrochloride (VAN) - Trifluoperazine hydrochloride tablets
Authoritative Data Verified Data
This product contains trifluoperazine hydrochloride (C21H24F3N3S • 2HC1) should be 90.0% ~ 110.0% of the label.
trait
This product is sugar-coated tablets, white or almost White after removing the coating.
identification
- take this product, remove the coating, grind, take a proper amount of fine powder (about 10mg of trifluoperazine hydrochloride), add 5ml of water, shake to dissolve trifluoperazine hydrochloride, filter, 1ml of nitric acid was added to the filtrate, and the solution changed from pink to brown. The solution was yellow after heating.
- the solution under the content measurement was measured by ultraviolet-visible spectrophotometry (General 0401), and the maximum absorption was found at a wavelength of Nm.
- the aqueous solution of this product was chloride identification (1) of the reaction (General 0301).
examination
- relevant substances: take an appropriate amount of fine powder of this product, add mobile phase to dissolve and make a solution containing 0.5mg of trifluoperazine hydrochloride per 1 ml, filter, and take the continued filtrate as the test solution; take 1 ml accurately, put it in a 200ml measuring flask, dilute it to the scale with mobile phase, shake it, and use it as a control solution. Take another dextrin, and add the mobile phase to make a solution containing about 2mg per lml, filtration, take the filtrate as a blank control solution. If there are impurity peaks in the chromatogram of the test solution, the area of a single impurity peak shall not be greater than the area of the main peak of the control solution (0.5% ), the sum of each impurity peak area shall not be greater than 2 times (1.0%) of the main peak area of the control solution.
- Content uniformity protected from light. Take 1 tablet of this product, put it in mortar, add appropriate amount of hydrochloric acid solution (1-20), grind, dissolve trifluoperazine hydrochloride, remove insoluble matter, use hydrochloric acid solution (1-20) quantitative dilution is made into solution containing 10ug per lml, and the content shall be determined according to the method under the content determination item, and shall comply with the regulations (General rule 0941).
- dissolution rate protected from light. Take this product, according to the dissolution and release determination method [general principles 0931 The first method (5mg specification) or the third method (lmg specification)], with 0.lmol/L hydrochloric acid solution 900ml(5mg specification) or 200ml(lmg specification) is the dissolution medium, the rotation speed is 50 rpm, the operation is carried out according to law, after 45 minutes, take 10ml solution, filter, the absorbance of the filtrate was measured at a wavelength of 0401 nm by UV-Vis spectrophotometry (General 630), and the elution amount of each tablet was calculated based on the absorption coefficient of c21h24f3n33.2hc1 being. The limit is 75% of the labeled amount and shall be in accordance with the provisions.
- others shall be in accordance with the relevant provisions under the item of tablets (General rule 0101).
Content determination
operation in the dark. Take 20 tablets of this product, remove the coating, precision weighing, fine, precision weighing an appropriate amount (equivalent to 10mg of trifluoperazine hydrochloride), put it in a 100ml measuring flask, add hydrochloric acid solution (1-20) appropriate amount of trifluoperazine hydrochloride dissolved, and diluted to the scale, shake, filter, precision take the continued filtrate, with hydrochloric acid solution (1-20) quantitative dilution of the solution containing 10ug per 1 ml, according to UV-visible spectrophotometry (General 0401), determination of absorbance at the wavelength of 256nm, the absorption coefficient of C21H24F3N3S · 2HC1 was calculated as 630.
category
with trifluoperazine hydrochloride.
specification
(l) lmg (2)5mg
storage
light shielding, sealed storage.
Last Update：2022-01-01 14:20:12
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Product Name: Trifluoperazine Dihydrochloride Visit Supplier Webpage Request for quotationCAS: 440-17-5
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Spot supply
Product Name: Trifluoperazine Dihydrochloride Visit Supplier Webpage Request for quotationCAS: 440-17-5
Tel: 18301782025
Email: 3008007409@qq.com
Mobile: 18021002903
QQ: 3008007409
Wechat: 18301782025
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